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Significados de genome instability em inglês
russo
геномная нестабильность espanhol
inestabilidad genómica Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.
Sinônimos
Examples for "genetic instability"
Examples for "genetic instability"
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However, our data impressively demonstrate the genetic instability in this chromosomal region.
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Oxidative DNA damage seems to contribute to genetic instability observed in cancer.
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Background: Latent genetic instability has been associated with an increased risk for several cancers.
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However, their inherent genetic instability hinders application for prophylactic purposes.
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Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma.
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Cells from patients with genomic instability syndromes have high predisposition to cancer.
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Deregulated activation of β-catenin in cancer has been correlated with genomic instability.
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Moreover, the different patterns of alteration imply distinct underlying mechanisms of genomic instability.
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NOS-induced ROS release leads to DNA damage and genomic instability in DMD hPSC.
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Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability.
Uso de genome instability em inglês
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Our present knowledge of the molecular basis underlying genome instability is extremely limited.
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Here, we present evidence that MLL2 mutation results in genome instability.
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Cells with a faulty protective mechanism undergo defective mitosis, leading to genome instability.
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Human MLL2 knockout cells are characterized by genome instability as well.
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Defects in the genes encoding the Paf1 complex can cause increased genome instability.
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Mutations in proteins that constitute these repair pathways are characterised by radiosensitivity and genome instability.
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Our data showed that additional transcription unit insertion could confer genome instability and attenuation of HP-PRRSV.
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We therefore propose that sequential degradation ensures orderly S-phase progression to avoid replication stress and genome instability.
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Thus, neither genome instability nor lack of immunosurveillance conferred by scid contributes to intestinal polyps in this model.
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The de novo assembly resulted in unmasking hidden genome instability that was missed by standard re-alignment based algorithms.
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The pre-BCR also promotes cell cycle entry, which could cause aberrant DSB repair and genome instability in pre-B cells.
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Retrotransposons are populated in vertebrate genomes , and when active, are thought to cause genome instability with potential benefit to genome evolution.
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Our studies provide new insights into understanding the genomic landscape, genome instability, and mutation profile underlying gastric cancer and ESCC development.
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Epigenetic perturbations are increasingly described in cancer cells where they are thought to contribute to deregulated gene expression and genome instability.
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From E. coli to yeast to human cells, subtle alterations in expression of BER proteins lead to mutagenic or genome instability phenotypes.
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We propose that loss of HR control after deregulation of RTEL1 may be a critical event that drives genome instability and cancer.
Translations for genome instability